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pentobarbital will minimize the extent or influence of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Pitolisant publicity is lessened by fifty% if coadministered with potent CYP3A4 inducers.Hypnotic doses of these barbiturates do not show up to considerably impair uterine exercise in the cou